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The Hemp Blog


Unveiling the Enigmatic World of Cannabis Trichome Glands: Nature's Microscopic Treasure Troves

Cannabis has long captivated human interest not only for its recreational and medicinal properties but also for its intriguing biological features. Among these features, the cannabis trichome glands stand out as tiny yet potent structures that play a significant role in the plant's physiology and pharmacology. Trichomes, the hair-like outgrowths on the surface of cannabis plants, are rich reservoirs of bio-active compounds, housing a plethora of cannabinoids, terpenes, and other constituents. In this article, we delve into the captivating world of cannabis trichome glands, exploring their structure, function, and the diverse array of compounds they contain.

Structure of Cannabis Trichome Glands

Trichomes are specialized epidermal outgrowths found on the surface of various plant species, including cannabis (Cannabis sativa). In cannabis plants, trichomes typically appear as glandular structures protruding from the surface of leaves, stems, and flowers. These microscopic glands come in different forms, with the most common types being bulbous, capitate-sessile, and capitate-stalked trichomes.

1. Bulbous Trichomes: These are the smallest and simplest type of trichomes found on cannabis plants. They consist of a small, spherical head attached directly to the epidermal cells.

2. Capitate-Sessile Trichomes: Capitate-sessile trichomes are slightly larger and more complex than bulbous trichomes. They feature a glandular head without a stalk and are often found on the surfaces of leaves and stems.

3. Capitate-Stalked Trichomes: These are the largest and most abundant type of trichomes on cannabis flowers. They have a stalk that elevates the glandular head above the surface of the plant. Capitate-stalked trichomes are primarily concentrated on the bracts, or floral leaves, of female cannabis flowers, where they play a crucial role in cannabinoid biosynthesis.

trichome gland heads used for hash making
Trichome Glands, stalk and heads.

Function of Cannabis Trichome Glands

Trichomes serve multiple functions in cannabis plants, including protection against herbivores, UV radiation, and pathogens. However, their most significant role lies in the production and storage of secondary metabolites, particularly cannabinoids and terpenes. Cannabinoids, such as tetrahydrocannabinol (THC) and cannabidiol (CBD), are unique phytochemicals that interact with the endocannabinoid system in humans and other animals, producing a wide range of physiological and psychological effects.

The biosynthesis of cannabinoids occurs predominantly within the glandular head of capitate-stalked trichomes. Biosynthetic pathways involving enzymes such as tetrahydrocannabinolic acid synthase (THCAS) and cannabidiolic acid synthase (CBDAS) convert precursor molecules into various cannabinoids, which are then stored in the glandular trichome secretions. Additionally, trichomes also produce terpenes, aromatic compounds that contribute to the distinctive flavors and aromas of different cannabis strains. Terpenes, such as myrcene, limonene, and pinene, have been shown to exhibit various therapeutic properties, including analgesic, anti-inflammatory, and anxiolytic effects.

Contents of Cannabis Trichome Glands

The contents of cannabis trichome glands are incredibly diverse, encompassing a complex mixture of cannabinoids, terpenes, flavonoids, and other phytochemicals. The primary constituents found in trichome secretions include:

1. Cannabinoids: THC and CBD are the most abundant cannabinoids present in cannabis trichomes, although many other cannabinoids, such as cannabinol (CBN), cannabigerol (CBG), and tetrahydrocannabivarin (THCV), are also present in varying concentrations.

2. Terpenes: Cannabis trichomes produce a wide array of terpenes, which contribute to the plant's aroma, flavor, and therapeutic effects. Common terpenes found in cannabis include myrcene, limonene, pinene, linalool, and beta-caryophyllene.

3. Flavonoids: Flavonoids are aromatic compounds with antioxidant and anti-inflammatory properties. While less studied than cannabinoids and terpenes, flavonoids such as cannflavin A and cannflavin B have been identified in cannabis trichomes and may contribute to the plant's pharmacological effects.

4. Phytocannabinoid Acids: In addition to neutral cannabinoids like THC and CBD, cannabis trichomes also contain their acidic precursors, such as tetrahydrocannabinolic acid (THCA) and cannabidiolic acid (CBDA). These acidic cannabinoids have been shown to possess unique pharmacological properties and may contribute to the overall therapeutic profile of cannabis products.


Cannabis trichome glands represent nature's microscopic treasure troves, housing a remarkable diversity of bioactive compounds with immense pharmacological potential. From cannabinoids and terpenes to flavonoids and phytocannabinoid acids, the contents of these tiny structures play a crucial role in shaping the therapeutic properties and sensory characteristics of cannabis strains. Understanding the structure, function, and contents of cannabis trichomes is essential for elucidating the complex chemistry of the plant and harnessing its therapeutic potential for various applications.

In layman's terms:

Cannabis is covered in trichome glands during the 8-10 week (or however long the cultivar demands) flowering period. All of the plant's cannabinoids and terpenes originate and reside in the heads of these trichome glands. Freezing the plant during harvest, allows for only the heads of each trichome glands to easily break free from the plant and be suspended in water until they are filtered out. A perfect six star grade ice water hash contains nothing but these round trichome gland heads, while live rosin contains only the contents of each trichome gland. All the rest of the plant, serves it's purpose by producing these trichome glands we're after. And to state the obvious, yes, this is where the plant's THC-a is produced and remains for our enjoyment (along with CBD and hundreds of other cannabinoids and terpenes).



1. Andre, C. M., Hausman, J. F., & Guerriero, G. (2016). Cannabis sativa: The plant of the thousand and one molecules. Frontiers in plant science, 7, 19.

2. Happyana, N., Agnolet, S., Muntendam, R., Van Dam, A., Schneider, B., Kayser, O., & Verpoorte, R. (2013). Analysis of cannabinoids in laser-microdissected trichomes of medicinal Cannabis sativa using LCMS and cryogenic NMR. Phytochemistry, 87, 51-59.

3. Potter, D. J. (2009). The propagation, characterisation and optimisation of Cannabis sativa L. as a phytopharmaceutical. PhD thesis, King’s College London.

4. Sirikantaramas, S., & Taura, F. (2017). Cannabinoid biosynthesis in Cannabis sativa: an overview. Methods in enzymology, 595, 79-90.


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